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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingTherefore, this review aimed to classify the management of NSCLC with driver mutations based on the geneThirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeuticmutations.This review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine   Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia     Identification novel mutations    

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Detection of critical road roughness sections by trend analysis and investigation of driver speed interaction

Meltem SAPLIOGLU; Ayse UNAL; Melek BOCEK

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 4,   Pages 515-532 doi: 10.1007/s11709-022-0814-4

Abstract: Pavement roughness (IRI—International Roughness Index values) influence the stability of traffic movements both on intercity roads and urban roads. This study is to determine the exact locations of critical pavement roughness values that affect traffic motion stability and comfort in city centre highway arteries. Roughness data with 10 m intervals were collected on a 3140 m divided road containing three consecutive signalized intersections in the city centre arterial. These data were analysed using the distance-dependent Mann-Kendall trend analysis method and checkerboard model. The sections where roughness is important were determined at a 95% confidence interval. The results will show where future pavement improvements should be prioritized for municipalities and road maintenance engineers and will form a basis for the urban road management system.

Keywords： trend analysis     checkerboard model     IRI     driver speed    

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Distributed governance of Solar Radiation Management geoengineering: A possible solution to SRM’s “free-driver

Andrew LOCKLEY

Frontiers of Engineering Management 2019, Volume 6, Issue 4,   Pages 551-556 doi: 10.1007/s42524-019-0055-y

Abstract: However, this low cost leads to a risk of controversial unilateral intervention—the “free-driver” problemFree-driver deployment scenarios previously considered include the rogue state, Greenfinger (Bodansky

Keywords： geoengineering     Solar Radiation Management     governance     decentralised    

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Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 51-59 doi: 10.1007/s11684-019-0720-x

Abstract: with mutations and the relation between mutations and tuberculosis (TB) transmission.Twenty-nine nonsynonymous single mutations and three double mutations were identified.The mutations at locus 483 (11.3%) were predominant, and the mutations at V483G, W484G, I491V, L516PFifteen new mutations in the gene were identified.Rifampin resistance and mutations at locus 531 were significantly associated with mutations.

Keywords： tuberculosis     drug resistance     compensatory mutations     transmission    

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122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutationsHBV mutations were determined by direct sequencing.Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (HBV) mutations    

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Approaching the upper boundary of driver-response relationships: identifying factors using a novel framework

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 6, doi: 10.1007/s11783-023-1676-2

Abstract:

● A novel framework integrating quantile regression with machine learning is proposed.

Keywords： Driver-response     Upper boundary of relationship     Interpretable machine learning     Quantile regression    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemiaHowever, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlybased on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutationswere mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Fuel type preference of taxi driver and its implications for air emissions

Feng WANG,Beibei LIU,Bing ZHANG,Jun BI

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 4,   Pages 702-711 doi: 10.1007/s11783-014-0665-x

Abstract: Natural gas became an available fuel for taxis in 2005 and had occupied a market share of 43.6% in taxi industry till 2010 in Nanjing, China. To investigate the energy replacement pattern as well as the pollutants reduction potential of the taxi industry, first, the fuel preference determinants of taxi drivers for their next taxis are analyzed. Results show that as an important alternative for the traditional gasoline, natural gas is widely accepted (75%) by taxi drivers. Different from the previous studies which focused on the early stage of cleaner fuel replacement, taxi drivers with various characteristics (such as age, working experience, and education level) are consistent with their fuel preference when they choose their next taxis. Result suggests that policies that concern consumers with specific characteristics may have little effects on the change of the market share, when the alternative fuel market has been developed well. In addition, the increased share of gas in the fuel market achieves a 7.2% reduction of energy consumption. Considering life cycle emissions, the following air pollutants, namely Greenhouse Gases (GHGs), carbonic oxide (CO), nitrogen oxide (NO ), particulate matters (PM) and hydrocarbons (C H ), gain 10.0%, 3.5%, 20.5%, 36.1%, and 26.4% of reduction respectively. Assuming all taxi fleets powered by natural gas with local policy intervention, the energy conservation and the five major air pollutant emissions could achieve the maximum reductions with 12.2%, 16.0%, 8.8%, 22.5%, 44.2%, and 49.4% correspondingly.

Keywords： fuel preference     energy replacement     environmental impacts     taxi    

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Experimental Study on the Piezoelectric Prestage Driver of Electrohydraulic Servo Valves

CHENG Guang-ming, SHEN Chuan-liang, YANG Zhi-gang

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 1,   Pages 56-59 doi: 10.1007/s11465-005-0017-4

Abstract:

A piezoelectric actuated prestage driver of hydraulic servo valves for the low-frequency responseof electrohydraulic servo valve electromagnetic prestage driver was presented.The new driver was driven by piezoelectric multilayer actuators.

Keywords： flexure-hinged amplifier     kHz     amplification     high-frequency     electromagnetic    

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Design and Developing of the Network Device Driver on Embedded Access Point

Wang Zhili,Hu Aiqun,Song Yubo

Strategic Study of CAE 2005, Volume 7, Issue 10,   Pages 91-94

Abstract:

This paper systematically introduces the main structure of network device driver based on embeddedThe testing results of the network device driver are given at the end of the paper.

Keywords： embedded linux     network device driver     PCMCIA    

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Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection Review

Jiachao Zhang,Rob Knight,

Engineering 2023, Volume 20, Issue 1,   Pages 96-102 doi: 10.1016/j.eng.2021.11.018

Abstract: More human microbiome research projects—particularly those that explore genomic mutations withinWe also explore the correlation between microbial genomic mutations and common metabolic diseases, andFinally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations

Keywords： Gut microbiota     Genomic mutations     Adaptive evolution     Purifying selection     Single-nucleotide variants    

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Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 419-429 doi: 10.1007/s11684-010-0160-0

Abstract: The association of viral mutations and haplotypic carriages with mutations in the preS region of hepatitis, and G3191C were significantly associated with increased risks of HCC in genotype C, whereas these mutationsConclusively, the association of HBV mutations in the preS region with HCC depends on HBV genotype andhaplotypic carriage with two or more mutations that are each associated with an increased risk of HCC

Keywords： hepatitis B virus     hepatocellular carcinoma     mutation     genotype     haplotype    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Over recent years, novel gene mutations have been found in patients with AML.These mutations can be divided into two important categories, class I mutations that confer a proliferationadvantage and class II mutations that inhibit myeloid differentiation.Screening for some of these mutations is now part of the initial diagnostic work-up in newly diagnosedBesides chromosomal rearrangements and gene mutations, epigenetic regulation of genes – meaning

Keywords： acute myeloid leukemia     mutations     risk stratification    

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract:

Neural tube defects (NTDs) are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.

Keywords： planar cell polarity     neural tube defects     rare mutations    

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Title Author Date Type Operation

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Journal Article

Detection of critical road roughness sections by trend analysis and investigation of driver speed interaction

Meltem SAPLIOGLU; Ayse UNAL; Melek BOCEK

Journal Article

Distributed governance of Solar Radiation Management geoengineering: A possible solution to SRM’s “free-driver

Andrew LOCKLEY

Journal Article

Characteristics of compensatory mutations in the

Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao

Journal Article

122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Approaching the upper boundary of driver-response relationships: identifying factors using a novel framework

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Fuel type preference of taxi driver and its implications for air emissions

Feng WANG,Beibei LIU,Bing ZHANG,Jun BI

Journal Article

Experimental Study on the Piezoelectric Prestage Driver of Electrohydraulic Servo Valves

CHENG Guang-ming, SHEN Chuan-liang, YANG Zhi-gang

Journal Article

Design and Developing of the Network Device Driver on Embedded Access Point

Wang Zhili,Hu Aiqun,Song Yubo

Journal Article

Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection

Jiachao Zhang,Rob Knight,

Journal Article

Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article